In-vitro Release of Paracetamol from Suppocire Suppositories: Role of Additives

Paracetamol is commercially available in oral and rectal dosage forms for geriatric and pediatric patients. Limitation of oral drug delivery for pediatric patient is inconvenience to swallow the tablet, capsule and oral suspension; in such case suppositories are effective and often used. To achieve successful delivery of drug locally as well as systematically, rectal route has proved its potential. The main objective of this research was to evaluate the potential of Suppocire suppository bases and study the effect of incorporation of ionic and nonionic surfactants on in-vitro release characteristic of paracetamol. Suppocire bases evaluated were interesterified Suppocire bases (Std type) e.g. Suppocire D and C, esterified bases (N-type) e.g. Suppocire NCX and amphiphilic bases (P-type) e.g. Suppocire CP. Effect of various additives such as sodium lauryl sulfate (SLS), dioctyl sulfosuccinate (DOSS), Labrasol, lecithin, Miglyol 812, aerosil, Capryol PGMC (CPGMC) and span 80 were studied on drug release. Paracetamol Suppocire suppository using amphiphilic base in combination with Labrasol showed optimal drug release as compared to other Suppocire bases. The developed paracetamol Suppocire suppositories gave controlled as well as fast release depending upon the additives added to the formulation and proved to be a good suppository base. Newly incorporated additives such as Labrasol and Capryol PGMC have promise to be used as adjuvants in suppository formulation.